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This disease may occur in newborns within 6 months after birth, as characterized by vomiting, developmental delay, serious progressive liver failure, hypotonia, hyperreflexia, irritability, and hypoglycemia

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It has been documented that BP from a corn tree ( Quercus acutissima ) is reported as an excellent antioxidant and anti-melanogenesis agent due to the presence of high amount of phenolic acids, and its possible mode of action is the obstruction of melanin-producing enzyme (tyrosinase) ( On the other hand, free phenolics are digestible in the small intestine while bound phenolic compounds are not absorbed (in the small intestine) and reached in the large intestine where they pass the fermentation process (by colon microbiota) and liberate bound phenolic compounds