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*Correspondence: Patrick Connerty, [email protected] These authors have contributed equally to this work and share senior authorship ORCID: Yashar Mesbahi, orcid.org/0000-0002-1730-9309 This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The procedure involves: Identifying one or more trigger points in one or two muscles Sterilizing the injection site Inserting a needle into the taut muscle band Injecting medication to relieve pain, reduce inflammation, and improve function These injections may be performed for a variety of clinical conditions, including myofascial pain syndrome, fibromyalgia, neck and back pain, and sports-related muscular tightness

To confirm that BAK1 and PEPR1 are internalized together, we purified clathrin-coated vesicles (CCVs) from Arabidopsis pRPS5A-PEPR1-GFP / pepr1pepr2 seedlings and examined whether BAK1 was present alongside PEPR1 in the enriched CCV fractions after treatment with Pep1 (500 nM for 20 min)