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Strbe et al., 2021), with one or two vessel ligations (Vukojevic et al., 2018

What they found: Plasma NAD+ did not rise directly , it was rapidly metabolized Plasma nicotinamide and methyl-nicotinamide rose markedly , markers of NAD+ metabolism NAD+ likely reaches tissues as its metabolites (not as whole NAD+) Clinically, patients subjectively reported increased energy during and after the infusion No serious adverse events during the 6-hour IV infusion Why it matters: The study provides rare clinical data on IV NAD+ , the administration route used by NAD+ clinics off-label

The constant activation of the Leydig cells means a slightly suboptimal dose is required due to otherwise excess aromatisation of Testosterone to Oestradiol Disappointingly, neither HCG nor Oestradiol are mentioned within the BSSM guidelines

Comments submitted after July 9 but before the July 22 docket closure will still be considered by FDA, but will not go directly to the Committee