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Its ingenious design avoids the drawbacks of traditional oral and injection routes: The spray formulation enables MT-1 peptides to directly enter the bloodstream through the mucous membranes rich in capillaries in the mouth or nose, completely avoiding the degradation effect of enzymes in the gastrointestinal tract and the first-pass effect of the liver, thereby significantly improving bioavailability and achieving rapid onset within minutes

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Also, publication bias could change the effects of NAC on E2 levels and endometrial thickness

Chavoshi Nezhad N et al