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The American Society of Transplant Surgeons consensus statement on normothermic regional perfusion

Specifically, a study focusing on heart IRI demonstrated that mitophagy was induced during the ischemia phase by FUNDC1 dephosphorylation to block apoptotic signals, while during the reperfusion phase, an increase in RIPK3 disrupted FUNDC1 activation to increase the likelihood of apoptosis [57], which could limit the protective effect of mitophagy