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A commentary on the extent of historical livestock losses attributed to selenosis on western US rangelands

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Furthermore, the administration of isoliquiritigenin reversed the downregulation of mitochondrial biogenesis-related proteins, including Nrf2, HO-1, Sirt1 and PGC1-, in human chondrocytes

The most common initial symptom in this large series, observed in 68% of the patients when first seen, was the insidious onset of proximal leg stiffness followed by rigidity concurrently in the abdominal, lumbosacral and thoracic paraspinal muscles, lumbar hyperlordosis and impaired gait