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Indeed, the efficacy of melatonin has been tested against the oxygen radical diseases of newborn, giving promising results 100,101,102 (Fig

Synthesis of ROS-sensitive polymers (P3) To a solution of ROS sensitive compound (2,2-(propane-2,2-diylbis(sulfanediyl))bis(ehan-1-ol)) (0.26 g, 1.35 mmol) in anhydrous DMF (5 ml), 1,2,4,5-cyclohexanetetracarboxylic dianhydride (0.31 g, 1.41 mmol) was quickly added into the solution

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Blood samples were collected from dogs administered multiple doses at corresponding time points before the first dosing (0 h), within 6 h after dosing, before the last three doses, and at corresponding time points after the last dosing