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We calculated a single somatic FF subdomain score as: muscular pain + muscle tension + fatigue + autonomous symptoms + GIS symptoms + headache + a flu-like malaise (thus excluding the cognitive and affective symptoms)

Issues raised in academic and consumer reviews include irritation in cosmetic-formulation use, very wide variation in product quality across the unregulated marketplace, formulation-stability problems, ingredient-interaction concerns, and a thin clinical-trial evidence base relative to the strength of consumer marketing claims

Eye care is also essential and involves using lubricating eye drops and taping the eye shut at night