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10.1093/ajcn/nqac040 [PMC free article: PMC9170474] [PubMed: 35470384] [CrossRef] Zamora-Ros R, Cayssials V, Clries R, Torrents M, Byrnes G, Weiderpass E, et al

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Collectively, the apoE4 variant appears to be associated with low cholesterol and poor lipidation, which, together with domain interactions, decreases its stability leading to impaired neuronal lipid metabolism and changes in lipidome profile that alters the brain innate immunity response to AD pathologies

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