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Rompp, A

In contrast, individuals from higher-income backgrounds are more likely to afford a varied, nutrient-rich diet and have access to antioxidant supplements or specialized treatments [38]

Unfortunately, no data on the impact of riboflavin supplementation on the vaginal microbiome composition or endogenous vaginal lactobacilli have been reported, making it difficult to assess whether an increase in lactobacilli by riboflavin could play a role in these observed enhanced antifungal effects 81

However, this effect was not reproduced in vivo: in the ileum and colon of metformin-treated mice, GLUT1 expression was markedly increased, whereas ATF4 levels remained unchanged (Supplementary Fig