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[DOI] [Google Scholar] 218.Nascimento N.P.d., Vinhal Borges .G.A., de Castro J.S., Nascimento C.P.d., Bitu L.A., de Sousa P.H.M., da Silva E.M.C

2021 May 12;19:53

6 Therapy of gastrointestinal disorders The gut microbiota plays a crucial role in human gastrointestinal health and the development of various diseases

The end products of purine metabolism, uric acid, a potent antioxidant, have been reported to be found in decreased levels in MDD 71,72,73 , while lower cerebro-spinal fluid (CSF) levels of hypoxanthine and xanthine, the two metabolites preceding uric acid, have previously been linked with depression 74