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In preferred embodiments, Ab is an anti-FRa antibody comprising either: (a) a variable heavy chain polypeptide comprising HCDR1 of SEQ ID NO:1 , HCDR2 of SEQ ID NO:2, HCDR3 of SEQ ID NO:3 and a variable light chain polypeptide comprising LCDR1 of SEQ ID NO:4, LCDR2 of SEQ ID NO:5 and LCDR3 of SEQ ID NO:6

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Others have strong mechanistic evidence with clinical data still emerging

Additionally, LC regulates pyruvate dehydrogenase activity through its reaction with acetyl-CoA, as well as proteolysis and protein synthesis necessary for maintaining the protein balance in skeletal muscle