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In summary, by strongly promoting SOD1 disulphide formation, ebselen facilitates correct folding and zinc acquisition of mutant SOD1 in the cytosol, while in less reducing environments it greatly enhances the SOD1 dimer affinity (Fig

It is characterized by the raising of the skin (swelling) at the injection site because of fluid leaking into the tissue (wheal)

Adaptive governance principles, which balance flexibility (loose coupling) with policy alignment (tight coupling), emerged as a promising framework for addressing these challenges