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Natural compounds should be given more thought, since they can have extended therapeutic time windows, good pharmacological targets, and little side effects

doi:10.3945/jn.114.201293 de Paz-Lugo P, Lupiez JA, Melndez-Hevia E

JAMA Pediatr [Internet]

Paradoxically, endogenous SAM accumulation or exogenous SAM treatment inhibits CRC proliferation, induces apoptosis (178, 179), and reverses promoter hypomethylation of oncogenes such as c-Myc and Ras (180)