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In vivo and ex vivo imaging studies indicated that A2-APM quickly detected the low-density lipoprotein receptor-related protein 1 (LRP1) on endothelial cells and GBM cells after intravenous treatment, to boost aPD-L1 and PTX entry into the tumor environment of GBM, resulting in substantially increased accumulation of antibodies in the brain in several tumor xenograft models, compared to free aPD-L1 group

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NAC helps to refill glutathione levels in the body

2.2 Phenylpropanoid synthesis of anthocyanin An aromatic phenyl group with six carbons and a propane side chain with three carbons make up phenylpropanoids