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Magnification bars are 2 m LTI significantly destroyed the sciatic nerves normal histology and many damaged nerve fibers were discovered, and several sciatic nerves in this group showed severe nerve fiber degeneration

Meanwhile, the occurrence of depression involves complex molecular mechanisms related to dysfunction of the monoaminergic nervous system, abnormality of the hypothalamic pituitary adrenal axis, imbalance of calcium homeostasis and calcium signaling pathways, mitochondrial dysfunction, autophagy, cell apoptosis, and oxidative stress (Villa et al., 2018

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Colombo S, Ronchetti D, Thevelein JM, Winderickx J, Martegani E (2004) Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae