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Phase I clinical trial of MP470 had been announced in 2007

In 1977, Caspary and Creutzfeldt proposed a mechanism that was how bacterial overgrowth in the intestine resulted in bacterial binding with IF-B12 complex instead of the latter getting absorbed [86]

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Maintenance Treatment Following First-line Pemetrexed Plus Platinum Chemotherapy The efficacy of pemetrexed as maintenance therapy following first-line platinum-based chemotherapy was also evaluated in PARAMOUNT (NCT00789373), a multi-center, randomized (2:1), double-blind, placebo-controlled study conducted in patients with Stage IIIb/IV non-squamous NSCLC who had completed four cycles of pemetrexed in combination with cisplatin and achieved a complete response (CR) or partial response (PR) or stable disease (SD)