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During the initial fatty streak phase of atherosclerosis (Figure 1), the monocyte-derived macrophages internalize the retained apoB-containing lipoproteins, which are degraded in lysosomes, where excess free cholesterol is trafficked to the endoplasmic reticulum (ER) to be esterified by acyl CoA:cholesterol acyltransferase (ACAT), and the resulting cholesteryl ester (CE) is packaged into cytoplasmic lipid droplets, which are characteristic of foam cells (42) (Figure 2) (44,45)

Their results show that the availability of extracellular GSH can alter sensitivity to different treatments, or even confer resistance to drugs that block the uptake of these amino acids, with the implications that entails

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Additionally, rare but serious side effects may occur, such as allergic reactions, difficulty breathing, chest pain, or irregular heartbeat