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The dose of fentanyl we chose for this study (75 g/kg, IV) elicited a robust decrease in minute ventilation (approximately 50% over a period of at least 60 min) and so represents a substantial level of ventilatory impairment by which to examine the effects of the 100 mol/kg dose of GSHee

While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

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Mice were given access to food and tap water ad libitum