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Furthermore, a marked decline of IGF-I has also been related to a higher probability of hepatocarcinoma[217] and poorer prognosis in patients requiring liver surgery[218]

Caco-2 and HT29-MTX cells were seeded in a 96-well plate at a concentration of 10 5 cells/well at a 90:10 ratio (Caco-2:HT29-MTX) in complete DMEM+1% MEM