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The discovery by researchers in the 19th century that coli toxins can trigger the activity of the immune system against tumors set the precedent for bacterial immunotherapy (Karbach et al., 2012)

An imbalance exists between the production of ROS and the capacity of antioxidants within the cell gives rise to oxidative stress, a condition linked to irreversible cellular damage that ultimately causes hearing loss due to auditory impairment (Wang and Puel 2018)

The standard procedure and reagents from the Q5 Site-Directed Mutagenesis kit (NEB) were used to insert mutations, ligate plasmids and transform them into NEB 5 competent cells by heat shock

Front Pharmacol 11:591561