Morris D, Ly J, Chi PT, et al
Abbreviations Abs: Apoptotic bodies A: Amyloid betaprotein AD: Alzheimers disease APTEMED: Ammonium persulphateN,N,N,N-Tetramethylethylenediamine BBB: Bloodbrain barrier BDNF: Brainderived neurotrophic factor bEnd.3: Brain microvascular endothelial cells BMn: Manganese dioxide nanozymes BSA: Bovine serum albumin BV2: Microglial cells C6: Coumarin6 CalceinAM: Calcein Acetoxymethyl Ester CAT: Catalase CCK8: Cell Counting Kit8 CLSM: Confocal laser scanning microscopy CNS: Central nervous system DCFHDA: 2',7'-Dichlorodihydrofluorescein diacetate DLS: Dynamic light scattering DMEM: Dulbecco's Modified Eagle Medium DMPO: 5,5dimethyl1pyrroline Noxide DOTAP: 1,2Dioleoyl3trimethylammoniumpropane ELISA: Enzymelinked immunosorbent assay ESR: Electron spin resonance EVs: Extracellular vesicles FBS: Fetal bovine serum FITC: Fluorescein Isothiocyanate FTIR: Fourier transform infrared spectroscopy H&E: Hemolysis assays, hematoxylineosin H 2 O 2 : Hydrogen peroxide HR: Hemolysis rate HRP: Horseradish peroxidase HT22: Hippocampal neurons cells IBA1: Ionized calciumbinding adapter molecule1 ICPOES: Inductively coupled plasma optical emission spectrometer KD: CD44-knockdown LLC cells LAbs: Apoptotic bodies derived from brain metastatic tumor cells LLC: Lewis lung carcinoma LPS: Lipopolysaccharide Mn: Manganese MWM: Morris water maze NFTs: Neurofibrillary tangles O 2 : Oxygen OA: Okadaic acid ptau: Phosphorylated tau Papp: Apparent permeability coefficient PBS: Phosphatebuffered saline PI: Propidium Iodide PS: Phosphatidylserine PVDF: Polyvinylideneuoride Rapa: Rapamycin RBC: Red blood cell ROS: Reactive oxygen species SDSPAGE: Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis SOD: Superoxide dismutase TEER: Transendothelial electrical resistance TEM: Transmission electron microscopy ThT: Thioflavin T TMB: 3,3',5,5'Tetramethylbenzidine UV: Ultraviolet WB: Western blot XPS: xray photoelectron spectroscopy XRD: xray diffraction 8OHG: 8hydroxyguanosine References Arvanitakis Z, Shah RC, Bennett DAJJ
Metabolism of homocysteine thiolactone in human cell cultures
Early-phase trials incorporating agents like veliparib or gemcitabine have demonstrated response rates up to 45%, and mirvetuximab soravtansine has shown an ORR of 71% and mPFS of 15 months (NCT02606305) [73]
