In normal aging, a decline in brain mitochondrial respiration and antioxidant enzymes has also been observed
Lewerenz, J., et al., The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities
Disclosures: Carla Barberan Parraga: Nothing to Disclose, Leandro Sierra: Nothing to Disclose, Diana Cheung: Nothing to Disclose, Kundan Jana: Nothing to Disclose, Marwan Alsaqa: Nothing to Disclose, Nazli Begum Ozturk: Nothing to Disclose, Butros Fakhoury: Nothing to Disclose, Syed Kodilinye: Nothing to Disclose, Ahmed Salem: Nothing to Disclose, Yasutoshi Shiratori: Nothing to Disclose, James Park: Nothing to Disclose 2449 GLYCINE-BETA-MCA SHOWS COMPARABLE ANTI-CHOLESTASIS BUT BETTER ANTI-FIBROSIS EFFICACY THAN UDCA IN FEMALE CYP2C70 KNOCKOUT MICE Mohammad Nazmul Hasan 1 Yung-Dai Clayton 1 Lijie Gu 1 Yanhong Du 1 Tiangang Li 1 , 1 The University of Oklahoma Health Sciences Center Background: Cholestasis is a chronic liver disease with limited therapeutic options
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