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In experiments testing the reversibility of RNS-mediated PDHC inhibition, reactions were subsequently incubated with an excess of DTT (10 mM) or buffer control at room temperature for 30 min before measuring activity

Nassireslami et al., 2016

More importantly, PKM2 can translocate into the nucleus, where it regulates the transcription of metabolic genes such as HIF-1, LDHA, and GLUT1, thereby enhancing glycolysis, suppressing OXPHOS, and establishing a metabolic firewall against therapeutic stress [97]

Other research points to no interaction between COMT, MOA A, and OCD.[ref] You can check your COMT variants below and learn more in this article: COMT gene variants and neurotransmitter metabolism MAO Genotype Report: Both the MAOA and MAOB genes are located on the X chromosome