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Dysbiosis-induced disruption of the gut-thyroid axis contributes significantly to the development and progression of hypothyroidism, particularly in autoimmune forms such as Hashimotos thyroiditis

10.1016/j.ajhg.2018.12.001 42

However, there are arguments that L-asparaginase together with glutaminase inhibitor may exert a complete inhibition of glutamine metabolism and so enhancing the anti-tumor effect in cancer cells [37, 48]