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Genetic modifiers such as the presence of an E4 allele of apolipoprotein E (ApoE) or polymorphisms in the methylenetetrahydrofolate reductase gene ( MTHFR ) may contribute to age of WD onset but these studies await confirmation in larger, independent populations

Succinate drives the production of IL1, mediated by HIF1 (39) whereas citrate accumulation leads to the production of itaconate, a potent inhibitor of isocitrate lyase, which is necessary for Mtb persistence (43)

The three variants are already a staple in the household