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Description

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the secondary C3-amine derivative intermediate e.g., compound 9) may then be methylated to obtain the desired cation (e.g., compound 1f)

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Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]