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At approximately age 16 years, he developed severe rectal prolapse with profuse bleeding on defecation

J Neurochem 156(6):9881002 Podvin S, Jiang Z, Boyarko B, Rossitto L, Donoghue AO, Rissman RA et al (2022) Dysregulation of Neuropeptide and tau peptide signatures in human Alzheimers disease brain