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Figure 3: Mitochondrial ROS production via Reverse Electron Transport

Accumulating evidence shows that resveratrol inhibits some oncogenic miRs, such as miR-19, miR-21, and miR-30a-5p, which is subsequently accompanied by the suppression of their target genes including epidermal growth factor receptor (EGFR), STAT3, cyclooxygenase (COX)-2, and NF-B, and subduing PI3K/Akt/mTOR signaling [133]

This activation cascade promotes mitochondrial biogenesis and enhances the efficiency of cellular energy production, contributing to improved metabolic health and resilience

This can help keep the kidneys clean and lower the chance of kidney stones