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While several double-blind RCTs demonstrate therapeutic potential particularly in reducing hyperactivity, irritability, and enhancing social functionings (Voigt et al., 2024), other trials fail to show benefits on core ASD symptoms (Mazzone et al., 2024)

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160 Extracellular eNAMPT has cytokine functions acting through TLR4, and in human lung endothelial cells, eNAMPT activates an inflammatory response through the NFB signaling pathway