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The advantages of nanoparticle-based therapeutic systems primarily lie in their ability to enhance drug stability, prolong circulation time, and enable site-specific delivery

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Mitochondria are a major source of intracellular reactive oxygen species (ROS), whose accumulation is buffered by GSH-dependent enzymes (Handy et al, 2009

The level of oxidative stress, quantified by the oxidative stress markers, has been found elevated in aging individuals or people with bad lifestyles, taking unhealthy food, smoking, drinking alcohol, lack of physical exercise, and genetic predisposition