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Studies indicate that the bioactivity of natural products may be closely related to their biotransformation by the gut microbiota

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They also increase mitochondrial glutathione levels by activating the Nrf2 signaling pathway, which plays a pivotal role in triggering inflammation.[xxvii] The ketogenic diet also stimulates autophagy in the brain, helping to clear away cellular damage to neurons.[xxviii] Finally, the ketogenic diet effectively reduces neuroinflammation by inhibiting the NF-kB inflammasome and producing the pro-inflammatory cytokines TNF-alpha and COX-2.[xxix] Patients with concussions and post-concussive syndrome can be challenging to treat