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In view of the pivotal role played by GSH in redox system and the relationship between oxidative stress and autophagy 68 , it is conceivable that GSH depletion-induced oxidative stress and lipid peroxidation may be a key point linking ferroptosis and autophagy in RPE cells

Oxidative stress is the consequence of the imbalance between the bodys immune system mechanisms and reactive oxygen species (ROS), resulting in cellular damage (85)

This condition can be detected through a complete blood count (CBC) test, which is commonly ordered during routine health check-ups or when symptoms suggest an infection or immune system disorder

However, following multiple overdoses which is the predominant mode of paediatric overdose has been reported [15, 51, 5658]