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The relevance of IGF-IR in the pathogenesis of thyroid-associated ophthalmopathy (TAO), the most serious extra-thyroidal autoimmune manifestation of Graves disease (GD), has only come into prominence over the past 2 decades ( IGF-I and Its Associated Pathway The molecular structure of IGF-I is closely related to insulin ( Figure 1 )

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3 , e156 (2005)

Tirzepatide and sermorelin together represent a combination therapy approach that some patients and clinicians consider for metabolic management, though this pairing lacks formal clinical study