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Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis

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The following tumours have been observed: a) By oral administration hepatocellular carcinomas and neoplastic nodules in female rats haemangiosarcomas in various circulatory system organs in male rats alveolar/bronchiolar adenomas in male and female mice b) By inhalation exposure nasal cavity carcinomas and adenocarcinomas in male and female rats alveolar/bronchiolar carcinomas in female rats alveolar/bronchiolar carcinomas in male and female mice haemangiosarcomas in the circulatory system of male and female rats mesotheliomas in male rats mammary fibroadenomas in female mice subcutaneous fibrosarcomas in female mice c) By skin administration skin papillomas and lung papillomas in female mice 7.7.1 Administration by gavage 7.7.1.1 Mouse When technical grade 1,2-dibromoethane (99.1% pure) in corn oil was administered on 5 consecutive days per week by gavage to B6C3F 1 mice (groups of 50 males and 50 females in the treated groups, and 20 of each sex in the untreated and vehicle control groups) at time- weighted average dose levels of 62 and 107 mg/kg per day, early development of squamous cell carcinomas of the forestomach was observed in both sexes