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In SURPASS-2, a head-to-head diabetes trial, Tirzepatide 15 mg outperformed Semaglutide 1 mg, producing 11.2 kg weight loss versus 5.7 kg (Frias et al., NEJM 2021

Semaglutide users usually begin experiencing appetite suppression within the first 1 to 2 weeks, with meaningful weight loss becoming visible by weeks 4 to 8 and continuing to progress over the following months