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Nevertheless, they are still useful as second-line agents to induce remission in CD when other agents, such as biologics fail[1]

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Subcutaneous Injection (Most Common Route) Subcutaneous injections deliver peptides just under the skin, allowing slow absorption and consistent therapeutic effects while minimizing discomfort

At concentrations of 1 pM1 nM, DSIP stimulated calcium-dependent release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro suggesting any antinociceptive effects observed in animal models may be mediated through endogenous opioid peptide release rather than direct receptor binding [7]