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doi: 10.1021/jf030022f

Importantly, homocysteine levels, which should be around 7.0, can be increased due to folic acid deficiency independent of B12 deficiency

Some HMs indirectly impose oxidative stress through a variety of mechanisms, including the depletion of glutathione, the binding of sulfhydryl groups of proteins (Jaishankar et al., 2014), the inhibition of antioxidative enzymes, or the induction of ROS-producing enzymes such as NADPH oxidases (Singh et al., 2015)

Mitochondrial disease activates transcripts of the unfolded protein response and cell cycle and inhibits vesicular secretion and oligodendrocyte-specific transcripts