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In addition, as mentioned previously that MMP-2 was significantly increased in leiomyoma cells, Curcumae rhizoma was also reported to inhibit the expression of MMP-2 which could also contribute to its use in the treatment of UF (Chen et al., 2011)

investigated the impact of DZN on gene expression related to spermatogenesis (activin, androgen receptor, and FSH receptor) and sex hormones in male zebrafish exposed to different DZN concentrations (5, 10, and 20% LC 50 ) for one month

Xu Y, Lv D, Yan C, Su H, Zhang X, Shi Y, et al

Free radicals and the role of plant phytochemicals as antioxidants against oxidative stress-related diseases, in Phytochemicals-source of antioxidants and role in disease prevention (InTech)