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Diverse membrane sourcesincluding erythrocytes [12], platelets [13], leukocytes [14], cancer cells [15], stem cells [16], and hybrid membranes [17])demonstrate unique properties

For instance, CerS1 is mainly expressed in the brain, CerS2 is highly abundant in the liver and kidney, high ex- pression of CerS3 is found in the testis and skin, and elevated levels of CerS4 mRNA are found in the skin, heart, liver, and leukocytes, CerS5 is mainly expressed in lung epithelia and brain, whereas CerS6 show high expression in the intestine (Brachtendorf et al., 2019

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However, under oxidative stress or pathological conditions like AGEs (72), Nrf2 is activated and translocated to the nucleus, initiating the expression of antioxidant genes such as GPX4, which are essential for reducing lipid peroxidation and delaying ferroptosis (73)