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As a nitrogen donor, it contributes to the synthesis of other non-essential amino acids, including the purines and pyrimidines, and is therefore essential for the proliferation of most cells (29)

[ 413 ] A bioinformatics analysis of patients with DN identified a negative connection between BACH1 level and glomerular filtration rate (FGR), indicating that BACH1 may have a nephrotoxic function in DN

Additional studies are ongoing and more evidence of the benefit of treating SMM is needed before this becomes a standard of care

Studies have shown that DFO-treated mice exhibit reduced ROS in cardiomyocytes, while patients with coronary heart disease experience improved endothelium-dependent vasodilation (189-191)