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Enzymes are an integral part of metabolic reactions, and EVs directly regulate metabolic enzymes, thereby modifying whole cellular metabolic processes

Overexpression of NQO1 in skeletal muscle and eWAT from NQO1-Tg mice was accompanied by the inhibition of the anabolic response and protein translational activity of mTORC1 in both organs, which could ultimately result in stress reduction in the liver and improved hepatic function

Consequently, oxidative stress occurs, and when it becomes excessive, it can lead to muscle damage