macula melanotica Oral Melanotic Macule: Symptoms and Treatment Labial Lentigo (labial melanotic macule)

Medicine (Baltimore) 2015;94:e702

This situation emphasizes the importance of proper clinical development for peptide therapeutics

It is known that reduction in CD38 expression on BM and circulating MM cells occurs rapidly after daratumumab initiation with significantly lower expression levels after the first infusion compared with baseline (potentially due to elimination of MM cells with high CD38 levels, endocytosis, or release in microvesicles), that may persist for at least 6 months after discontinuation [35]

Interestingly, here also we found that plumbagin could strongly inhibit the cysteine-free molecule, indicating that it was also functioning in a manner very similar to juglone (data not shown)