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mRNA-4157 (V940) is an mRNA-based personalized neoantigen therapy by encoding up to 34 tumor-specific antigens in a lipid nanoparticle formulation and tailored specifically for cancer patients, subsequently stimulating the immune system to produce reactive T cells targeting patient-specific tumor neoantigens, thereby achieving the goal of controlling and treating tumors

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Similar inconsistent findings were also shown in other clinical studies (Scholze et al., 2014