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*Correspondence to: Carsten Berndt, Department of Neurology, Medical Faculty and University Hospital Dsseldorf, Heinrich-Heine University, Dsseldorf 40225, Germany

Since L-dopa is converted to dopamine in the CNS and the peri phery, peripheral conversion and systemic effects can be reduced by combining L-dopa with carbi dopa (a peripheral decarboxylation inhibitor), which does not cross the bloodbrain barrier