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For example, FAD-free NQO1 or a cancer-associated P187S mutant form of NQO1 exhibits reduced FAD binding and is degraded by the ubiquitinproteasome system 53,60

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In Figure 4 It was observed that, compared to the normal architecture and regular pattern of hepatocytes with active vesicular nuclei in G1 (Normal control), the liver of G2 (MTX) showed central vein dilation and congestion (a in Figure 4B), Focal cell necrosis, hepatocyte nuclei of many cells are dark stained, and small apoptosis was also observed

The canonical and noncanonical NF-B pathways differ in signaling mechanisms but are responsible for regulating inflammatory responses [17]