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Price: 24.60 USD
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[DOI] [PubMed] [Google Scholar] 991.Fernandes Q, et al

The G12C mutation introduces a cysteine residue at the codon 12, enabling covalent inhibitors to selectively bind and lock KRAS in its inactive GDP-bound state

25 While functional changes for patients after treatment were not published for this therapy, these preliminary findings suggest that further investigation of JNJ-1887 is warranted

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