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Factors released by neighbouring -cells or -cells amplify the glucose-induced effects on somatostatin secretion from -cells, which act locally within the islets as paracrine or autocrine inhibitors of insulin, glucagon and somatostatin secretion

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An unhealthy body due to the presence of far too much lipid peroxidation is likely to experience ferroptosis more often than someone who is healthy, redox stable, and has low oxidative stress