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CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture

Such an imbalance is responsible for severe damage to essential biomolecules, such as lipids (lipid peroxidation), proteins (oxidation and inactivation), and DNA (strand breakage and mutations), which is associated with the pathogenesis of numerous diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and the aging process [28]

258 While in the mitochondrial respiration-impaired cells, NAD + could reduce the exacerbated inflammatory response via improving lysosomal function

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