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Although the specific mechanisms by which gender influences systemic metabolic variations in PD patients with mutations in GBA1 , LRRK2 , TMEM175 , PARK2 , PINK1 , and PARK7 are not yet fully understood, taken together our NMR results indicates that sex plays a prominent role in shaping unique serum metabolomic profiles in familial PD compared to controls

The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) will directly compare one representative medication from four different classes: sulfonylureas (glimepiride), dipeptidyl peptidase-4 (DPP-4) inhibitors (sitagliptin), glucagon-like peptide-1 (GLP-1) receptor agonists (liraglutide) and basal insulins (glargine) in a long-term clinical trial in patients with diabetes for 10 years or less [6]

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